I’m almost afraid to get started on this topic, I might not shut up. To keep it short, between harping on the sensational key words of the article (tic tacs/placebos) and bypassing the equally if not more important point mentioned (i.e. not all antidepressants help all types of depression), I would hardly promote this as an “excellent overview” (jayparkinsonmd) given the amount of territory not covered that this topic inherently encompasses. To blame big pharma and biased clinical studies while overlooking FDA minimum success rate requirements to release such novel treatments into market that are arguably no better than a sugar pill is just a part of it. But if it helps a small percentage, say 5%…well 5% of 27m is quite a lot.  Also, I’d be interested to see a break down of scripts written by Primary Care Physicians vs. Psychiatrists vs. Psychopharmacologists by type of depression  AND given the amount of psychological diagnostic training each profession receives AS WELL AS how many are referred to a psychologist. In the article. Hollon, DeRubeis, et al note, “Prescribers, policy-makers, and consumers may not be aware that the efficacy of [antidepressants] largely has been established on the basis of studies that have included only those individuals with more severe forms of depression,” something drug ads don’t mention. People with anything less than very severe depression “derive little specific pharmacological benefit from taking medications. Pending findings contrary to those reported here … efforts should be made to clarify to clinicians and prospective patients that … there is little evidence to suggest that [antidepressants] produce specific pharmacological benefit for the majority of patients.”  With the amount of underlying questions not covered here or in the article (protocols, screening tools for studies, etc-and to discuss ethics, see ohheygreat’s commentary with jayparkindsonmd)  gives me the impression this is a broad simplification at how anti-depressants don’t help all types of depression. I just think this deserves more consideration/scrutiny than the headlines here suggest. IDK, its late…what do you think?