New chemical reagent turns biological tissue transparent.
As someone who worked with fluorescence labeling & microscopy using immunohistology, this groundbreaking reagent seems promising. The resulting 3D images provide a deeper understanding of spacial depth and detail as well as better sub-cellular resolution, it seems pretty fantastic. These scientists use mouse brains, which we didn’t, but I wish we had this when I was doing that. 

So, what’s the benefit? ABOVE: A 3D shot of the hippocampal neurons from the Dentate gyrus to the surface. And a little more exciting to me, since I compared left Dentate gyrus to right. BELOW we have something that can show the whole enchilada all at once in 3D. Amazing, just look at that detail. The Japanese scientists have plans to use this technique on other organs as well in living tissue.

Images and article via. H/T@TheNeuroScience

New chemical reagent turns biological tissue transparent.

As someone who worked with fluorescence labeling & microscopy using immunohistology, this groundbreaking reagent seems promising. The resulting 3D images provide a deeper understanding of spacial depth and detail as well as better sub-cellular resolution, it seems pretty fantastic. These scientists use mouse brains, which we didn’t, but I wish we had this when I was doing that

So, what’s the benefit? ABOVE: A 3D shot of the hippocampal neurons from the Dentate gyrus to the surface. And a little more exciting to me, since I compared left Dentate gyrus to right. BELOW we have something that can show the whole enchilada all at once in 3D. Amazing, just look at that detail. The Japanese scientists have plans to use this technique on other organs as well in living tissue.

Images and article via. H/T@TheNeuroScience