Posts tagged depression

One of the most common observations in psychotherapy of people with depression or anxiety is that they hold themselves to impossibly high standards, although they have a perfectly sensible evaluation of everyone else. Their own failures are catastrophic; other people’s are minor setbacks. Other people’s successes are well-deserved triumphs; their own are never good enough, flukes, they don’t count.

The first step in challenging these unhelpful patterns of thought is to simply point out the double-standard: why are you such a perfectionist about yourself, when you’re not when it comes to other people? The idea being to help people to think about themselves in more like healthy way they already think about others. Turn the map of yourself upside down - what do you actually see?

Neuroskeptic (more)

Newsweek: Antidepressants Depressingly Wonky

I don’t even know if I have the energy to launch into this, let alone all the variables/issues this article didn’t touch.  Not saying I disagree, just that this is a small piece of a larger issue…ok we’ll hash it out over drinks. 

one molecule -macrophage migration inhibitory factor- opens the door to new TXs for depression
"MIF is normally thought to play a role in tissue swelling and even cancer development, but its precise location and function in the brain remained a mystery. (…) Genetically and pharmaceutically manipulating the level of MIF in the hippocampus of rats, the researchers discovered that the absence of MIF significantly reduced the production of neurons and increased anxiety They also found that the lack of MIF decreases the ability of anti-depressants to stimulate neurogenesis. These findings have led the researchers to conclude that MIF plays an important role in neurogenesis and, in turn, the condition of anxiety and depression."

one molecule -macrophage migration inhibitory factor- opens the door to new TXs for depression

"MIF is normally thought to play a role in tissue swelling and even cancer development, but its precise location and function in the brain remained a mystery. (…) Genetically and pharmaceutically manipulating the level of MIF in the hippocampus of rats, the researchers discovered that the absence of MIF significantly reduced the production of neurons and increased anxiety They also found that the lack of MIF decreases the ability of anti-depressants to stimulate neurogenesis. These findings have led the researchers to conclude that MIF plays an important role in neurogenesis and, in turn, the condition of anxiety and depression."

Law Practice Can Trigger Stress Disorder, Says Attorney Who Now Works as Therapist

…”A little dose of anxiety is being injected into you, in the form of a thought.Anxiety is triggered by cognition – predictive thoughts. You predict something bad is going to happen, so you clutch up in preparation – tense up and prepare for attack.”

"CB1 antagonists could do more than help people lose weight: they might also be useful in helping people quit smoking, alcohol or drugs. The animal evidence that CB1 antagonists did this was strong. Human trials were underway. Optimists saw rimonabant and related drugs as offering something unprecedented: self-control in a pill, abstinence on demand.
The problem was that they made people depressed. In several large clinical trials of rimonabant it raised the risk of suffering depression and other psychiatric problems, like anxiety and irritability, compared to placebo.
We still don’t know why they cause psychiatric symptoms, although a number of mechanisms have been suggested. Hopefully, someone will work this out sooner or later, since that would add an important piece to the puzzle of what goes on in the brain during depression…”
-click thru for Neuroskeptic’s full article.

"CB1 antagonists could do more than help people lose weight: they might also be useful in helping people quit smoking, alcohol or drugs. The animal evidence that CB1 antagonists did this was strong. Human trials were underway. Optimists saw rimonabant and related drugs as offering something unprecedented: self-control in a pill, abstinence on demand.

The problem was that they made people depressed. In several large clinical trials of rimonabant it raised the risk of suffering depression and other psychiatric problems, like anxiety and irritability, compared to placebo.

We still don’t know why they cause psychiatric symptoms, although a number of mechanisms have been suggested. Hopefully, someone will work this out sooner or later, since that would add an important piece to the puzzle of what goes on in the brain during depression…”

-click thru for Neuroskeptic’s full article.